Important Safety Information for Vardenafil 20 mg
dronedaronedronedarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- 20 mg vardenafil is considered a standard starting dose for many men.
- Consult a doctor if you experience prolonged or painful erections.
- Vardenafil is a phosphodiesterase inhibitor that promotes vasodilation.
- Do not crush or break the vardenafil tablets; take them whole.
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dronedarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors duvelisibduvelisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Alternative medication therapies
deferasirox will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. degarelixdegarelix and vardenafil both increase QTc interval. degarelix and vardenafil both increase QTc interval. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).
A comprehensive review of erectile dysfunction in men with diabetes
deutetrabenazine and vardenafil both increase QTc interval. dexamethasonedexamethasone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dexamethasone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DHEA, herbalDHEA, herbal will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DHEA, fildena professional 100 herbal will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. duvelisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. efavirenzefavirenz ed gels will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.efavirenz and vardenafil both increase QTc interval. efavirenz will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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elagolixelagolix decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Brand names
diltiazemdiltiazem will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors diltiazem will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dofetilidedofetilide increases toxicity of vardenafil by QTc interval. dofetilide increases toxicity of vardenafil by QTc interval. donepezildonepezil and vardenafil both increase QTc interval.
3.2 Dosing
dordavipronedordaviprone and vardenafil both increase QTc interval. Increase the frequency of ECG and electrolyte monitoring. dordaviprone and vardenafil both increase QTc interval. doxepindoxepin and vardenafil both increase QTc interval. doxepin and vardenafil both increase QTc interval. Consider increasing CYP3A substrate dose if needed.
Cialis (Tadalafil)
dabrafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darifenacindarifenacin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darifenacin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darunavirdarunavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration may increase PDE-5 inhibitor adverse effects fildena 200 mg including hypotension, syncope, visual changes, and prolonged erection; do not exceed vardenafil 2.5 mg q72hr.
Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: A systematic review and meta-analysis
darunavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dasatinibdasatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.dasatinib and vardenafil both increase QTc interval. dasatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. deferasiroxdeferasirox will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. elagolix decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Precaution | Explanation | Recommended Action |
|---|---|---|
| Cardiovascular Risk | Risk of sudden cardiac events | Medical evaluation required |
| Vision Disturbances | Rare side effect involving PDE6 | Seek medical attention if occurs |
| Alcohol Consumption | May increase side effects | Limit or avoid consumption |
| Renal Impairment | Alters drug clearance | Dose adjustment possibly needed |
Adjust vardenafil dose for ED; not to exceed single dose of 2.5 mg in 72 hr Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations.
- 20 mg vardenafil is effective in improving erectile function in most men.
- Be aware of potential allergic reactions, such as rash or swelling.
- The medication can interact with certain antibiotics and antifungals.
- Regular check-ups are recommended during prolonged use of vardenafil.
Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. entacaponeentacapone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Section snippets
crizotinibcrizotinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. crizotinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crofelemercrofelemer increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.
When to Seek Medical Attention
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. crofelemer increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclosporinecyclosporine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cyclosporine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dabrafenibdabrafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors entacapone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors erythromycin baseerythromycin base will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin base will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin lactobionateerythromycin lactobionate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Conflicts of interest
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cimetidinecimetidine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cimetidine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ECG monitoring is recommended, along with drugs that may prolong the QT interval. clarithromycinclarithromycin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 2.5 mg/24 hr clozapineclozapine and vardenafil both increase QTc interval.
What is Levitra
clozapine and vardenafil both increase QTc interval. cobicistatcobicistat will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors conivaptan will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cortisonecortisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cortisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin stearateerythromycin stearate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin stearate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr escitalopramescitalopram increases toxicity of vardenafil by QTc interval. escitalopram increases toxicity of vardenafil by QTc interval. eslicarbazepine acetate will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Transient decrease in heart rate and AV conduction delays may occur when initiating etrasimod. Owing to potential of additive effect on heart rate, etrasimod may increase risk of QT prolongation and Torsades de Pointes when coadministered with Class Ia or Class III antiarrhythmic drugs, or other drugs that prolong the QT interval.
- It is important to follow your healthcare provider’s dose instructions.
- Vardenafil is effective for men with diabetes-related erectile dysfunction.
- Taking vardenafil on a full stomach may delay its onset.
- The medication helps improve erectile response but does not increase libido.
etravirineetravirine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.